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IL-2/Ig protein and IL-2/Ig plasmid administration augment SIV Gag p11C-specific CTL responses in fresh PBL from the vaccinated monkeys. p11C-specific CTL responses were analyzed every 2 weeks by tetramer staining of fresh PBL. Staining with the Mamu-A*01/p11C tetramer was assessed by four-color flow cytometry on gated CD3+CD8+ lymphocytes. The most consistent and significant augmentation was observed in the monkeys that received IL-2/Ig plasmid. Means and SE for each group are shown.
