Figure 5. Effect of the myofilament Ca²⁺ sensitizer EMD 57033 on cardiac contractile function at a slow pacing rate (5 Hz).

A, representative pressure tracings recorded from hearts paced at 5 Hz at baseline, in the presence of isoproterenol (ISO, 0.1 μmol l⁻¹), in the presence of EMD 57033 (3 μmol l⁻¹), and in the presence of ISO and EMD. Comparison of average maximum developed pressure (B), end-diastolic pressure (EDP, C), peak +dP dt⁻¹ (D), peak −dP dt⁻¹ (E), normalized peak +dP dt⁻¹ (F), normalized peak −dP dt⁻¹ (G), ratio of peak −dP dt⁻¹ over peak +dP dt⁻¹ (H), and time to 90% relaxation (I). Data are means ±s.e.m.; *P < 0.05 versus baseline; †P < 0.0.5 versus EMD, ‡P < versus all other.