Table 1.

Baseline contractile parameters of isovolumetrically contracting mouse hearts paced at 10 Hz. For each heart, parameters were obtained at LV balloon volume that produced the maximum developed pressure

						ANOVA P-value
Parameters	NTG (n = 15)	WT-Tg (n = 5)	Control (NTG + WT-Tg) (n = 20)	I79N-Tg (n = 10)	R278C-Tg (n = 6)	NTG, WT, I79N, R278C	Control, 179N, R278C
End-diastolic pressure (mmHg)	19.39 ± 2.12	24.3 ± 7.1	20.7 ± 2.3	22.7 ± 1.9	23.8 ± 1	0.5620	0.6784
Developed pressure (mmHg)	76.16 ± 2.35	74.73 ± 5.57	76 ± 2.18	68 ± 2.2	71 ± 2.76	0.1478	0.0618
Peak +dP dt−1 (mmHg s−1)	3293 ± 125	3199 ± 339.7	3268 ± 122	2739 ± 88‡*	2847 ± 138.5	0.0283	0.0113
Normalized +dP dt−1	43.19 ± 0.68	42.51 ± 1.59	43 ± 0.63	41 ± 1.0*	40 ± 0.95*	0.0987	0.0486
Peak −dP dt−1 (mmHg s−1)	2461 ± 106	2503 ± 297.44	2472 ± 105	1749 ± 112‡*	1990 ± 77.4‡*	0.0007	0.0002
Normalized −dP dt−1	32.19 ± 0.61	33.12 ± 1.68	32 ± 0.61	26 ± 1.6‡§*	28 ± 0.38‡+*	0.0002	0.0002
Ratio +dP dt−1
to −dP dt−1	1.35 ± 0.03	1.29 ± 0.04	1.33 ± 0.02	1.6 ± 0.11‡§*	1.43 ± 0.04	0.0198	0.0051
TTR 90% (ms)	44 ± 0.7	44 ± 1.8	44 ± 0.7	48 ± 1.0‡§*	47.4 ± 0.4‡*	0.0049	0.0020
Balloon volume (μl)	34.2 ± 1.54	40.4 ± 3.56	35.8 ± 1.53	25.9 ± 1.21‡§*†	32.4 ± 1	0.0002	0.0003

Data are mean ±s.e.m.; control = combined data from NTG and WT-Tg

^‡P < 0.05 versus NTG

^§P < 0.05 versus WT

^*P < 0.05 versus control

^†P < 0.05 I79N-Tg versus R278C-Tg.