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. 2006 Jun 8;575(Pt 1):145–159. doi: 10.1113/jphysiol.2006.112730

Figure 1. Acute ethanol superfusion produced differential increases in proximal (somal) and distal (dendritic) GABAA IPSCs in ISS and ILS mice.

Figure 1

Responses were pharmacologically isolated using the competitive NMDA receptor antagonist, D-APV (50 μm) and the AMPA receptor antagonist, CNQX (30 μm) and are shown as insets above time courses. A, representative time course of the effect of 80 mm ethanol on the amplitude of proximal and distal GABAA IPSCs recorded from an ISS mouse. Ethanol (80 mm) did not significantly alter GABAA IPSCs in either the proximal or distal subregions of hippocampal pyramidal cells from ISS mice. B, representative time course of the effect of 80 mm ethanol on the amplitude of proximal and distal GABAA IPSCs recorded from an ILS mouse. Significant increases in proximal GABAA IPSCs were seen in ILS mice following ethanol treatment. C, summary of data showing the effect of ethanol (80 mm) on proximal and distal GABAA IPSCs from ISS and ILS mice. Number of neurons for each measurement: ISS proximal, n = 22; ISS distal, n = 15; ILS proximal, n = 21; ILS distal, n = 16. Scale for insets in A and B, 15 ms, 20 pA. ***P < 0.001.