Figure 6. Pretreatment with a GABA_B receptor antagonist failed to alter the effects of ethanol on either proximal or distal NMDA EPSCs from ISS or ILS mice.

Ethanol (80 mm) produced only a small, but significant decrease in proximal and distal NMDA EPSCs from ISS mice, whereas ethanol alone produced large reductions of both proximal and distal NMDA EPSCs from ILS mice. Pretreatment with CGP-52432 did not significantly alter the effect of ethanol on these NMDA responses from either ISS or ILS mice. Therefore, these results indicate that there were no subregional differences in the effect of ethanol on NMDA EPSCs, and CGP-52432 treatment did not change the effect of ethanol in these two hippocampal subregions. Number of cells for these experiments ranged from 6 to 12 for each individual determination. *P < 0.05; **P < 0.01.