Representative paired-pulse responses from proximal GABAA IPSCs from ISS and ILS mice (A) before and during application of 80 mm ethanol recorded using CsCl-filled electrodes. The PPR was determined as described in Figure 7A. The effect of BMI on ethanol-treated GABAA IPSCs shows almost complete inhibition for both ISS and ILS mice. B, summary data showing that ethanol significantly decreased PPR of GABAA IPSCs from both ISS and ILS mice. Number of cells recorded: ISS, GABAA, n = 5; ILS, GABAA, n = 5. Scales for A: ISS, 20 ms, 20 pA; ILS, 20 ms, 25 pA.