Table 1.
Effects of CGP-52432 and ethanol on GABAA IPSC paired-pulse ratios recorded from proximal and distal subregions of CA1 pyramidal neurons in ISS and ILS mice
| ISS | ILS | |||
|---|---|---|---|---|
| Proximal | Distal | Proximal | Distal | |
| Control | 0.64 ± 0.04 (8) | 0.56 ± 0.04 (6) | 0.63 ± 0.05 (8) | 0.72 ± 0.06 (11) |
| EtOH | 0.61 ± 0.05 (5) | 0.51 ± 0.04 (6) | 0.68 ± 0.04 (4) | 0.63 ± 0.04 (6) |
| CGP | 0.74 ± 0.06 (7) | 0.73 ± 0.05 (5) | 0.67 ± 0.08 (5) | 0.72 ± 0.02 (8) |
| CGP + EtOH | 0.73 ± 0.03 (8) | 0.72 ± 0.09 (8) | 0.64 ± 0.07 (8) | 0.77 ± 0.04 (10) |
Paired-pulse GABAA IPSCs were recorded with potassium gluconate-filled electrodes in the absence or the presence of ethanol (80 mm), CGP-52432 (CGP, 0.5 μm) or ethanol (EtOH) plus CGP-52432. The GABAA IPSC amplitude evoked by the second pulse was divided by the amplitude evoked by the first pulse to obtain a paired-pulse ratio. Paired-pulse depression was found in all GABAergic terminals recorded with these electrodes. The results are means ±s.e.m. of the number of neurons indicated in parentheses. No significant effect of treatment with respect to CA1 subregion or strain was indicated.