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. 2006 May 25;575(Pt 1):23–35. doi: 10.1113/jphysiol.2006.106351

Figure 4. Non-cholinergic evoked contractions of guinea-pig tracheal strips in vitro in the absence or presence of FM1-43 or FM2-10.

Figure 4

Concentration-response curves for contractions evoked by histamine (A) and [β-Ala8]-neurokinin A(4–10) (B) in guinea-pig tracheal strips in vitro in the presence of vehicle or 5 μm FM1-43. C, EFS-evoked non-cholinergic contractions of guinea-pig bronchial rings in vitro before (filled bars) and after (open bars) vehicle (DMSO), 50 μm FM2-10 or 5 μm FM1-43. Tissues were first treated with 1 μm atropine to prevent cholinergic responses. Contractions were abolished by 0.3 μm each of the neurokinin receptor antagonists CP-99 994 and SR48968 (not shown). Each data set represents the mean ±s.e.m. of n = 3–4 experiments and is expressed as a percentage of the maximum attainable contraction evoked by 300 mm BaCl2.