Skip to main content
. 2006 Jun 22;575(Pt 2):627–644. doi: 10.1113/jphysiol.2006.113985

Figure 5. Effects of AA metabolites on cardiac KATP channel activities in transgenic mice overexpressing CYP2J2.

Figure 5

Representative tracings of cardiac KATP currents (after subtraction of HMR-1098-insensitive K+ currents) were recorded from ventricular myocytes of WT mice (A) and transgenic mice overexpressing CYP2J2 (B), before (upper panels) and 15 min after (lower panels) the application of AA (1 μm). Baseline KATP current densities were 2-fold higher in the CYP2J2 transgenic mice than in WT. Exposure to 1 μm AA enhanced the KATP current densities in both WT and transgenic mice. C, KATP channel I–V relationships showing significant increase in current densities at voltages negative to EK on exposure to AA in both WT and CYP2J2 transgenic mice. *P < 0.05 AA versus baseline for both WT and CYP2J2 transgenic mice. n = 5 for WT and n = 6 for CYP2J2 transgenic mice; †P < 0.05 baseline of CYP2J2 versus baseline of WT; ‡P < 0.05 CYP2J2 transgenic with AA versus WT with AA.