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. 2006 Jun 22;575(Pt 2):627–644. doi: 10.1113/jphysiol.2006.113985

Figure 7. Effects of AA on cardiac KATP channel activities are abolished by treatment with miconazole.

Figure 7

HMR-1098-sensitive KATP currents were recorded in ventricular myocytes from WT (A) and CYP2J2 transgenic mice (B) preincubated with 10 μm miconazole (60 min), before (upper panels) and 15 min after (lower panels) the application of 1 μm AA. Treatment with miconazole not only abolished the effects of AA on KATP channel activities in both WT and CYP2J2 transgenic mice, but also reduced the baseline current densities of the CYP2J2 transgenic myocytes to that of WT. C, after treatment with miconazole, KATP channel I–V relationships showed no significant difference in KATP channel activities between WT and CYP2J2 transgenic cardiac myocytes before and after exposure to AA. n = 6 for both groups.