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. 2007 Mar 21;2(3):e312. doi: 10.1371/journal.pone.0000312

Figure 4. In vitro cellular responses to MMP-8 cleaved LIX.

Figure 4

(A) Enhanced intracellular calcium mobilization was induced by LIX (5-92) and LIX (5-79) compared to full-length LIX (1-92) in recombinant CXCR2-expressing B300-19 cells and (B) PMNs isolated from Mmp8-/- mice (100 nM chemokine). (C) By transwell cell migration assay, both LIX (5-92) and LIX (5-79) truncated forms are more potent chemoattractants compared with the full-length LIX (1-92) for both CXCR2-expressing B300-19 cell transfectants and (D) murine PMNs isolated from either Mmp8+/+ or Mmp8-/- mice, all at 10 nM chemokine concentration.