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α-GalCer-mediated protection against Trypanosoma cruzi is not observed in MHC II–/–, CD8α–/–, perforin–/– or silica-treated mice. Mice were treated with 5 μg α-GalCer or diluent and the next day were inoculated with 2 × 105 trypomastigotes. Five mice per group were monitored for parasitaemia (mean and SE) and five or more mice per group were monitored for survival. The results are representative of two or more experiments for each mouse strain.
