Table 1.

Expression patterns of GITR and GITRL in macrophages in different parts of atherosclerotic plaques

	GITR				GITRL
Tissues	Whole	M-I1	Core2	Shoulder3	Whole	M-I1	Core2	Shoulder3
#1	+ + + 4	+ + +	+ +	+ + +	+ +	+ +	–	+
#2	+ + +	+ + +	+ + +	+ + +	+ + +	+ + +	+ + +	+ +
#3	+ + +	+ +	+ + +	na	+ + +	+ + +	+ + +	na
#4	+ +	+ + +	na5	na	+ + +	+ +	na	na
#5	+ + +	+ + +	+ + +	+ +	+ +	+ +	+ +	+
#6	+ +	+	na	na	+ + +	+ + +	na	na
#7	+ +	+	+ + +	na	+ + +	+ +	+	na
#8	+ + +	+ +	+ +	na	+ +	+ + +	+ + +	na
#9	+ + +	+ +	+ +	na	+ +	+ + +	+ + +	na
#10	+ + +	+ + +	na	+ + +	+ +	+ + +	na	+
#11	+ + +	+ +	+ + +	na	+ + +	+ + +	+ + +	na

¹Boundary regions between media and intima

²areas around necrotic core

³shoulder regions of the plaque

⁴–, no expression; +, <30%; + +, 30–70%; + + +, >70% of macrophages express GTIR or GITRL

⁵na, not available because this area was not present in the tissue specimen.