Figure 6.

Effect of anti-IL-6 mAb treatment on T-cell and B-cell responses at 34 weeks of age. (a) Anti-CD3-stimulated T-cell proliferation was examined in splenocytes harvested when mice were 34 weeks of age. ATPlite assay was performed to determine T-cell proliferation and the results are expressed as cells per count (cps). (b) B-cell proliferation induced by anti-CD40/anti-IgM antibodies was assessed in splenocytes harvested when mice were 34 weeks of age. ATPlite assay was performed and the results are expressed as cps. (c) T-cell proliferation in MLR was examined in splenocytes harvested when mice were 34 weeks of age. ATPlite assay was performed and the results are expressed as cps. *p < 0·05 versus saline and isotype control mAb-treated groups.