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Anti-IL-6 mAb inhibited stat3 phosphorylation in T and B cells. Stat3 phosphorylation in T and B cells from saline, isotype control antibody, and anti-IL-6 mAb-treated NZB/W F1 mice was examined in splenocytes cultured with 40 ng/ml of recombinant mouse IL-6 for 6 min at 37°. Surface markers, CD4, CD19 and intracellular phosphorylated stat3 were determined by flow cytometry. Representatives of CD4+ T cells from 24-week-old mice and CD19+ B cells from 34-week-old mice are shown.
