Figure 2.

Simultaneous MTB infection of mouse strains deficient in selective β2-m-dependent functions. Survival and lung burden of β2-m^−/− (⧫), TAP1^−/− (★), CD8α^−/− (▴), perforin^−/− (●), and wild-type C57BL/6 (■) mice infected i.v. with (A) a high inoculum (1 × 10⁶ CFU) or (B) a low inoculum (1 × 10⁵ CFU) of MTB. (Upper) The percentage of survival of groups of 14 to 30 mice per strain. The differences in survival between all strains are statistically significant. (Lower) The lung burden of MTB at different time points after infection. Results are expressed as the means CFUs ± SEM of five mice per time point and per strain.