Abstract
The antiviral effect of 5% idoxuridine in dimethyl sulphoxide intermittently applied and of 40% idoxuridine in dimethyl sulphoxide continuously applied for four days to the lesions in patients with zoster of recent onset was studied in two double-blind controlled trials. Most, but not all, of the patients receiving intermittent active treatment had pain for a short period only. The effect of continuous treatment was striking: pain had disappeared within nine days in all the patients and healing was accelerated. The results were statistically significant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Calabresi P. Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections. Ann N Y Acad Sci. 1965 Jul 30;130(1):192–208. doi: 10.1111/j.1749-6632.1965.tb12552.x. [DOI] [PubMed] [Google Scholar]
- ELLIOTT F. A. TREATMENT OF HERPES ZOSTER WITH HIGH DOSES OF PREDNISONE. Lancet. 1964 Sep 19;2(7360):610–611. doi: 10.1016/s0140-6736(64)90507-0. [DOI] [PubMed] [Google Scholar]
- Eaglstein W. H., Katz R., Brown J. A. The effects of early corticosteroid therapy on the skin eruption and pain of herpes zoster. JAMA. 1970 Mar 9;211(10):1681–1683. [PubMed] [Google Scholar]
- Juel-Jensen B. E. Herpetic whitlows: results of treatment with idoxuridine. J Am Coll Health Assoc. 1970 Feb;18(3):227–230. [PubMed] [Google Scholar]
- Juel-Jensen B. E. Severe generalized primary herpes treated with cytarabine. Br Med J. 1970 Apr 18;2(5702):154–155. doi: 10.1136/bmj.2.5702.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MERSELIS J. G., Jr, KAYE D., HOOK E. W. DISSEMINATED HERPES ZOSTER. A REPORT OF 17 CASES. Arch Intern Med. 1964 May;113:679–686. doi: 10.1001/archinte.1964.00280110059012. [DOI] [PubMed] [Google Scholar]
- MacCallum F. O., Juel-Jensen B. E. Herpes simplex virus skin infection in man treated with idoxuridine in dimethyl sulphoxide. Results of double-blind controlled trial. Br Med J. 1966 Oct 1;2(5517):805–807. doi: 10.1136/bmj.2.5517.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mantel N. Ranking procedures for arbitrarily restricted observation. Biometrics. 1967 Mar;23(1):65–78. [PubMed] [Google Scholar]
- RAPP F., VANDERSLICE D. SPREAD OF ZOSTER VIRUS IN HUMAN EMBRYONIC LUNG CELLS AND THE INHIBITORY EFFECT OF LODODEOXYURIDINE. Virology. 1964 Mar;22:321–330. doi: 10.1016/0042-6822(64)90023-6. [DOI] [PubMed] [Google Scholar]