TABLE 1.
Tumors in Atf-2+/− mice
| Mouse | Sexa | Age (wk) | Site | Histologyb | Expressiond
|
|||
|---|---|---|---|---|---|---|---|---|
| Atf-2 | p53 | Maspin | Gadd45α | |||||
| T2 | F | 57 | Mammary gland | Idc. scirrhous | ND | ND | ND | ND |
| T1 | F | 70 | Mammary gland | Idc. scirrhous | ND | ND | ND | ND |
| T8 | F | 72 | Mammary gland | Idc. scirrhous | + | + | Red | Red |
| T5 | F | 73 | Mammary gland | Idc. scirrhous | − | − | − | − |
| T7 | F | 91 | Mammary gland | Idc. scirrhous | − | + | − | − |
| C21 | F | 86 | Mammary gland | Idc. squamous | − | + | − | − |
| T4 | F | 88 | Mammary gland | Idc. squamous | Red | + | − | − |
| C22 | F | 92 | Mammary gland | Idc. squamous | Red | + | − | Red |
| 104 | F | 60 | Mammary gland | Idc. anaplastic | Red | + | − | − |
| T6 | F | 62 | Mammary gland | Idc. solid-tubular | Red | + | Red | Red |
| T13 | F | 99 | Mammary gland | Idc. Papillary | − | Red | − | − |
| 105 | F | 64 | Mammary gland | Sarc. ca. spindle cell | − | − | − | − |
| C25 | F | 59 | Mammary gland | Unknown | + | + | Red | Red |
| T3 | F | 71 | Mammary gland | NDc | ND | ND | ND | ND |
| T16 | F | 103 | Mammary gland | ND | ND | ND | ND | ND |
a
F, female.
b
Idc. scirrhous, invasive ductal carcinoma with scirrhous invasion; Idc. squamous, invasive ductal carcinoma with squamous invasion; Idc. anaplastic, invasive ductal carcinoma with anaplastic invasion; Idc. solid-tubular, invasive ductal carcinoma with solid-tubular invasion; Idc. papillary, invasive ductal carcinoma with papillary invasion; Sarc. ca. spindle cell, sarcomatoid carcinoma with spindle cell invasion.
c
ND, not determined due to degradation of tumor tissues and mRNA.
d
+, the expression level was almost the same as that in the wild-type mammary gland; −, almost no expression; Red, the expression level was reduced to 10% to 60% of that in the wild-type mammary gland.