TABLE 1.
Body weight and blood chemistrya
| Gender and cell type | BW (g) | FFA (μEq/liter) | TG (mg/dl) | Glu (mg/dl) | PL (mg/dl) | TC (mg/dl) | LDH (IU/liter) | AST (IU/liter) | ALT (IU/liter) | 3-HBA (μmol/liter) |
|---|---|---|---|---|---|---|---|---|---|---|
| Male | ||||||||||
| WT | 24.9 ± 1.0 | 327.8 ± 75.6 | 66.6 ± 5.8 | 220.6 ± 11.5 | 143.0 ± 7.2 | 71.2 ± 4.9 | 77.6 ± 3.7 | 30.2 ± 0.7 | 19.6 ± 1.1 | 172.4 ± 10.9 |
| Lox | 24.9 ± 0.3 | 435.0 ± 49.6 | 52.8 ± 11.8 | 228.5 ± 21.2 | 141.0 ± 5.8 | 70.0 ± 4.2 | 93.5 ± 18.0 | 38.8 ± 3.4* | 25.0 ± 4.1 | 166.0 ± 37.4 |
| cKO | 24.5 ± 0.4 | 313.2 ± 69.7 | 82.0 ± 22.2 | 230.4 ± 27.1 | 131.2 ± 7.0 | 57.8 ± 5.1 | 130.4 ± 39.0 | 47.4 ± 6.0* | 30.2 ± 5.0 | 194.0 ± 18.8 |
| Female | ||||||||||
| WT | 20.6 ± 0.3 | 437.0 ± 45.5 | 66.8 ± 14.5 | 193.6 ± 9.5 | 130.6 ± 12.5 | 64.8 ± 7.9 | 72.0 ± 4.8 | 38.6 ± 3.2 | 18.0 ± 1.3 | 194.6 ± 35.5 |
| Lox | 20.8 ± 0.4 | 351.2 ± 81.7 | 49.8 ± 15.2 | 237.8 ± 13.3* | 132.6 ± 3.6 | 64.0 ± 2.2 | 77.0 ± 2.5 | 38.0 ± 3.4 | 18.8 ± 1.4 | 168.2 ± 18.8 |
| cKO | 20.0 ± 0.4 | 282.2 ± 55.5 | 38.6 ± 10.2 | 214.4 ± 12.7 | 138.6 ± 6.4 | 70.4 ± 4.8 | 80.2 ± 1.0 | 40.0 ± 1.3 | 20.8 ± 2.3 | 182.4 ± 25.0 |
a
WT, Acc1+/+ WT; Lox, Acc1lox(ex46)/lox(ex46) WT; cKO, Acc1lox(ex46)/lox(ex46) TgFabpl-cre; BW, body weight; FFA, free fatty acids; TG, triglyceride; Glu, glucose; PL, phospholipids, TC, total cholesterol; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; 3-HBA, 3-hydroxybutyric acid. *, P < 0.05 compared to WT. Data are expressed as average results ± standard errors (n = 4 to 5).