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USP8-deubiquitinating activity mediates NRG1-induced Nrdp1 accumulation. (A) 293T cells were cotransfected with ErbB2/3 and FLAG-Nrdp1, without and with V5-USP8 as indicated. Cells were treated without and with NRG1, and lysates were blotted with the indicated antibodies. (B) 293T cells were cotransfected with ErbB2/ErbB3 and FLAG-Nrdp1 and V5-tagged versions of either wild-type (wt) or inactive mutant (C748A) USP8.
