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A stepwise model for the formation of SAHF in senescent human cells. This model indicates the key steps in SAHF formation, after initiation by senescence triggers. Dashed lines are steps which are currently poorly defined (see text for details). Abbreviations: HMT, histone methyltransferase; Me, methylated lysine 9 histone H3; Ac, acetylated histone. HMGA proteins are shown in mature SAHF (56), but their point of entry is not known.
