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. 2000 Apr 11;97(8):4227–4232. doi: 10.1073/pnas.97.8.4227

Figure 3.

Figure 3

Stat3 tyrosine phosphorylation. (A) Immunoblotting of protein extracts (50 μg) from representative control normal mucosa from patients without cancer (C1–4), normal mucosa from SCCHN patients (N1–4), and SCCHN tumors (T1–4) using a phosphospecific anti-Stat3 p-TYR (705) antibody. The position of the phosphorylated Stat3 protein is indicated on the right. (B) Stat3 phosphotyrosine immunostaining showing basal epithelial expression in a representative normal mucosa from a patient without cancer. (C) Staining throughout the epithelium in a representative sample of normal mucosa from SCCHN patients. (D) Increased expression in a representative SCCHN tumor.