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. 2007 Mar 13;5(4):e70. doi: 10.1371/journal.pbio.0050070

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© 2007 Momose and Houliston.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Domain structure of CheFz1 and CheFz3 proteins compared to the Drosophila Frizzled protein. Blue boxes: cysteine-rich domains; Pink/red boxes: seven-pass transmembrane domains (transmembrane regions in red); green boxes: KTXXXW motif.

(B) Maximum likelihood analysis of relationships of Frizzled sequences from mouse (m), Drosophila melanogaster (Dm), and the known cnidarian Frizzleds: Hydra vulgaris, Hydractinia echinata, and N. vectensis (Nv). The tree was rooted using the Drosophila Smoothened sequence. Scale indicates number of inferred substitutions per site.