Table 5.
Hematologic toxicities (NCI-CTC grade) per cycle and per patient. NCI-CTC: National Cancer Institute Common Toxicity Criteria; Gr: grade; FN: febrile neutropenia; NS: not significant.
| Neutropenia | Thrombocytopenia | FN | Anemia | |||||
| Total | Gr 3 | Gr 4 | Gr 3 | Gr 4 | Gr 2 | Gr 3-4 | ||
| Number of patients (%) | ||||||||
|
| ||||||||
| Per cycle | ||||||||
| Phase II | 59 | 24 (40.7) | 9 (15.3) | 3 (5.1) | 2 (3.4) | 2 (3.4) | 15 (25.4) | 1 (1.7) |
| CU | 372 | 20 (5.4) | 8 (2.2) | 10 (2.7) | 3 (0.8) | 5 (1.3) | 33 (8.8) | 5 (1.3) |
| Total | 431 | 54 (12.5) | 17 (3.9) | 13 (3.0) | 5 (1.2) | 7 (1.6) | 48 (11.1) | 6 (1.4) |
| χ 2, P value | < .0001 | < .0001 | NS | .08 | NS | .0002 | NS | |
|
| ||||||||
| Per patient | ||||||||
| Phase II | 15 | 10 (66.7) | 5 (33.3) | 3 (20) | 2 (13.3) | 2 (13.3) | 6 (40) | 1 (6.7) |
| CU | 74 | 11 (14.9) | 6 (8.1) | 8 (10.8) | 3 (4.1) | 5 (6.7) | 18 (24.3) | 5 (6.7) |
| Total | 89 | 21 (23.6) | 11 (12.3) | 11 (12.3) | 5 (5.6) | 7 (7.9) | 24 (26.9) | 6 (6.7) |
| χ 2, P value | < .0001 | < .0001 | NS | NS | NS | NS | NS | |