Table 1.

Predictors of disease-free survival: Univariate and multivariate analyses

Factor	Coefficient	Hazard ratio	95% C.I.	P value
Univariate Cox model
No. of CD8+ TILs (continuous)	−0.06	0.94	(0.90, 0.99)	0.018
No. of CD8+ TILs (binary)
<8		1		reference
≥8	−0.8	0.45	(0.21, 0.96)	0.034
Age	0.01	1.01	(0.98, 1.05)	0.40
Disease stage
T1 or Ta		1		reference
T2+	0.79	2.21	(1.09, 4.49)	0.025
Carcinoma in situ
No		1		reference
Yes	−0.19	0.83	(0.37, 1.87)	0.650
Sex
Female		1		reference
Male	−0.13	0.88	(0.41, 1.85)	0.730
Chemotherapy
No		1		reference
Yes	0.37	1.44	(0.66, 3.14)	0.360
MHC class I (HLA) expression
≤10		1		reference
>10+	−0.64	0.53	(0.25, 1.12)	0.097
Multivariate Cox model
Disease stage T2+ (vs. T1/Ta)	1.66	5.28	(2.32, 13.62)	<0.001
No. of CD8+ TILs ≥8 (vs. <8)	−0.24	0.79	(0.27, 2.33)	0.670
Stage*CD8+	−1.59	0.2	(0.04, 0.90)	0.040