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AIP IHC. (A) AIP immunoreaction is observed in both the cytoplasm and the nucleus in normal adenohypophysis. (B) AIP expression in AIP-proficient adenoma. (C and D) AIP-deficient adenomas from two acromegaly patients bearing the p.Q14X mutation. There is complete loss of immunoreaction in adenoma cells, whereas AIP heterozygous peripheral blood leucocytes display positive immunoreaction, indicated by black arrows.
