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Loss of virulence in lpxF mutants of F. novicida. Three groups of 10 mice were injected into their right rear footpads with 106 viable wild-type F. novicida U112, 106 live vaccine strain (LVS), or 106 lpxF XWK4 mutant F. novicida. Survival of the animals was recorded once a day. (A) Average weights of the surviving animals. (B) Percentage of surviving animals in each treatment group.
