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Knockdown of PSD-95 impairs LTD. (a) Synaptic depression after pairing-induced LTD was not detected in Hp1-expressing neurons. (b) Average AMPA-EPSCs at −60 mV recorded before and 30–35 min after LTD induction. (Scale bars: 20 pA and 20 ms.) (c) Summary of changes after LTD: In control neurons, EPSCs decreased to 0.51 ± 0.08 of baseline (n = 11), significantly different from Hp1 (0.98 ± 0.18, n = 7, P < 0.02). Control pathways were stable (0.92 ± 0.16 and 0.98 ± 0.19).
