Fig. 1.

Behavioral phenotype of MUT mice. Hindlimb clasping dystonic phenotype in MUT (A) compared with WT (B). Clasping score is determined over 14 sec (WT, □; MUT, ■). (C) Predominantly sustained hindlimb clasping was observed by 12 wk. (D) Locomotor activity data (for distance) for MUT (female, ●; male, ■) and WT (female, ○; male, □). Hyperactive phenotype of MUT (age 10–11 wk) males and females is observed over a 4-day test. (E) MUT mice (black bars) showed a decrease in sifting and chewing and an increase in total rearing. ∗∗, P < 0.01; ∗, P < 0.05 vs. WT control.