Fig. 2.

Serial MRI and MRS analysis of MUT mice. (A) Schematic diagram delineating the MRI parameters used in the study. (B) Serial changes in the size of the striatum relative to the whole brain in WT (□) and MUT (■). There is an age-dependent reduction in R value [where R = (d3−d2)/d4] in MUT compared with WT littermates. (C) MRI coronal sections of a WT mouse (C) and a MUT mouse (D) at 8 wk showing enlargement of the lateral ventricles and striatal atrophy. (E) C/C changes in striatum with time (WT, white bars; MUT, black bars). (F) NAA/creatine ratio over time. Note significant difference in C/C to 8 wk. A decrease in NAA/creatine is seen at 30 wk in MUT. ∗∗, P < 0.01; ∗, P < 0.05.