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. 2007 Feb 13;5(3):e43. doi: 10.1371/journal.pbio.0050043

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© 2007 Nadel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) V(D)J recombination generating an ESJ.

(B) Ongoing V(D)J recombination of the ESJ with a RSS target in trans, leading to reintegration of the excised EC in the genome. The specific trans-CSJ and ΨHJ breakpoint signatures of the episomal reintegration are depicted.

(C) V(D)J-mediated translocation generating one trans-chromosomal CJ and one trans-CSJ.

(D) Ongoing V(D)J recombination of a CSJ in cis. The illustration depicts a CSJ generated through V(D)J-mediated translocation, but the same principle stands for a CSJ generated through V(D)J recombination by inversion.

White triangles, 12-RSS; black triangles, 23-RSS; dotted white triangles, IG/TCR or cryptic 12-RSS; rectangles, IG/TCR gene segment or oncogene activated through rearrangement; ellipses, RAG-1/2. Indicative chromosomes and derivative chromosomes are shown. Dented line in the ΨHJ and CJ represents processing at the junction (Δ, nucleotide deletion; P, P nucleotide addition; N, N nucleotide addition).