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. Author manuscript; available in PMC: 2007 Mar 13.
Published in final edited form as: Gastroenterology. 2006 Sep;131(3):878–884. doi: 10.1053/j.gastro.2006.06.013

Figure 3.

Figure 3

Electron micrographs of sandwich cultured hepatocytes. Hepatocytes were treated with PBS, Ad-siControl or Ad-siRadixin and cultured for 5 days. Hepatocytes treated with PBS (A) or Ad-siControl (B) developed dilated bile canaliculi. Tight junctions are intact and few microvilli are observed. The bile canalicular lumina of Ad-siRadixin treated cells were largely collapsed (C). The tight junctions remain intact and the loss of severe dilation results in the appearance of microvilli. BC, bile canaliculi. Bar = 2μm