Figure 7.

Genomic organization of IGN1 and structure of the translation product. A, Intron-exon structure of IGN1 gene. Exons are shown as boxes. B, Predicted amino acid sequence of IGN1 protein. The PEST sequence is boxed. ANKR, Ankyrin repeat (bold and underlined); TM, transmembrane domain (double underlined). C, Alignment of the seven ankyrin repeats of IGN1 with the ankyrin consensus. Amino acids identical to the consensus are shown as bold. Helices predicted by Predict-Protein are shown as white boxes. D, Mutation site in the ign1 genome.