Figure 6.

Transposons and mRNAs harboring transposon-derived sequences are misregulated in Dicer^−/− oocytes. (A) Quantitation of retrotransposon levels in Dicer^−/− oocytes by RT–PCR. Error bars indicate standard error of the mean. (B) Quantitation of repeat element representation in 3′UTRs of transcripts that are either up-regulated, down-regulated, or remain stable in the absence of Dicer. Values have been normalized to the percent 3′UTR repeat content of the unchanged set. Asterisk (*)denotes statistical significance (p < 1.0e−10) of repeat proportion difference (percent of 3′UTR contributed by repetitive elements) between two sets of transcripts calculated by prop.test in R package (http://www.r-project.org).