Figure 3.

(A) Detection of WHcAg in a uPA/RAG-2 mouse liver containing WHV-positive woodchuck hepatocytes by immunostaining with a WHc antiserum. A nodule containing transplanted WHV-positive woodchuck hepatocytes (lighter area, rhodamine light) and host mouse hepatocytes that presumably deleted the uPA transgene (darker stained area). (×200.) (B) DPPIV staining of bile canaliculi in uPA/RAG-2 mouse liver containing woodchuck hepatocytes. (×200.) Bile canaliculi are visible between mouse hepatocytes (darker staining) and transplanted woodchuck hepatocytes (lighter staining). Nuclei are counterstained with hematoxylin.