Table 3.
Gene ontology analyses of up-regulated genes.
| Gene lists used for comparison | Biological process category | Number of overrepresented genes/all genes in category (p-value) |
| Vac-4 up-regulated | Regulation of cell proliferation GO:0042127 | 7/181 (0.000) |
| Positive regulation of cell proliferation GO:0008284 | 5/80 (0.000) | |
| Wound healing GO:0042060 | 4/57 (0.001) | |
| Pol-8 up-regulated | Antigen processing (GO:0030333) | 3/39 (0.010) |
| Antigen presentation (GO:0019882) | 3/46 (0.016) | |
| Regulation of signal transduction (GO:0009966) | 6/175 (0.016) | |
| Regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043122) | 4/85 (0.017) | |
| Response to extracellular stimulus (GO:0009991) | 2/18 (0.018) | |
| Pol-16 up-regulated | DNA replication (GO:0006260) | 9/171 (0.000) |
| Response to wounding (GO: 0009611) | 8/213 (0.003) | |
| Regulation of signal transduction (GO:0009966) | 7/175 (0.004) | |
| Response to stress (GO:0006950) | 17/758 (0.007) | |
| Regulation of MAPK activity (GO:0043405) | 3/37 (0.009) | |
| RNA modification (GO:009451) | 2/16 (0.0015) | |
| Cell proliferation (GO:0008283) | 11/433 (0.017) |
The cells were incubated with poliovirus (Pol) for 8 or 16 h, or with vaccinia virus (Vac) for 4 h prior to microarray examination. Lists of up-regulated genes were compared with the lists of all the genes expressed in that experiment, using the Target-master statistical test available under GeneTools [37]. Only the more significant and more relevant results are presented. The total number of annotated, expressed genes was 10195.