Table 4.
Annotated candidate genes for viral defense listed alphabetically.
| Symbol | Name | Indication | Expression level | Induction | Comments |
| CXXC5 | CXXC finger 5 | Up in Pol-8, Vac-4, Ifn-8 and BKV | H | H | DNA binding/regulator of gene transcription |
| HMGB2 | High-mobility group box 2 | Induced by both Pol and Ifn (16 h) | H | M | DNA binding and regulation, cytokine |
| ITGAV | Integrin α5 | Down or border line down in all experiments | M-H | L (or just below L) | Membrane protein associated with adhesion and signal transduction, virus uptake |
| LY6E | Lymphocyte antigen 6 complex locus E | Induced by both Pol and Ifn (8 h) | M-H | M-H | Cell surface receptor involved in defense |
| LZTR1 | Leucine-zipper-like transcription regulator 1 | Induced by both Pol and Ifn (8 h) | H | H | Transcription regulator |
| MATN4 | Matrilin4 | Up in Pol-8, Pol-16, Vac-4, Ifn-16 and BKV | M-H | M-H | Extracellular matrix adapter? |
| MT1L | Metallothionein 2A | Induced by both Pol and Ifn (16 h) | H | M | Metal binding/homeostasis |
| PKM2 | Pyruvate kinase, muscle | Induced by both Pol and Ifn (8 h) | H | H | Kinase activity |
| RND3 | Ras homolog gene family E | Induced by both Pol and Ifn (16 h) | H | M | Actin cytoskeleton |
| SIGLEC1 | Sialoadhesin | Induced by both Pol and Ifn (8 h) | H | H | Immunoglobulin adhesion molecule on cell surface |
| UBC | Ubiquitin C | Induced by both Pol and Ifn (8 h) | H | H | Selective protein degradation |
Expression level: below 500 is low, 500–1500 medium, above 1500 high. Induction level: /log2/ between 0.6–0.9 is low, 0.9–1.2 medium, >1.2 high.