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. 2007 Mar 22;117(4):931–943. doi: 10.1172/JCI29031

Figure 2. Autistic-like behavior of Cadps2–/– mice.

Figure 2

(A) Number of reciprocal interactions of Cadps2–/– mouse pairs (black bar; n = 12) and of WT littermate pairs (white bar; n = 12) for 20 minutes. (B) Locomotor activity in home cages. After habituation to a fresh cage for 24 hours, the locomotor activity of Cadps2–/– mice (black bar; n = 9) and WT littermates (white bar; n = 9) was measured for 6 days (12-hour LD cycle [LD]). The number of photobeam interruptions per 15 minutes is shown in the y axis. (C–F) Horizontal locomotor activity of Cadps2–/– mice (filled circles; n = 15) and of WT littermates (open circles; n = 17) in an open field is shown in 3 blocks (5 minutes each) in the absence (C) or presence (D) of the novel object shown in the upper right of D. Representative movement traces of WT and Cadps2–/– are shown in E and F, respectively. Error bars indicate the SEM. *P < 0.05; **P < 0.01, by Student’s t test.