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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: Dev Biol. 2006 Oct 27;301(1):14–26. doi: 10.1016/j.ydbio.2006.10.035

Fig. 1. Cip/Kip family CKIs display distinct spatial expression patterns in the developing vertebrate spinal cord.

Fig. 1

(A) p21cip1 protein is expressed in cells located medial to Chx10+ V2 interneurons in the ventral spinal cord. (B) p57kip2 is expressed in two groups of cells at the lateral margins of the ventricular zone everywhere along the DV axis except in V2 and motor neuron (MN) domains (bracketed). (C) p27kip1 is widely expressed in cells located within the mantle zone (MZ). (D,E) p57 mRNA expression in E11.5 mouse and E4 chick embryos show a similar pattern of expression. (F) Summary of overlapping and unique expression patterns of CKIs during neurogenesis. (A–D) Show E11–11.5 mouse embryo, (E) is from a stage 22 chick embryo. All sections are through the thoracic region.