Table 1.
Neutralizing antibody response against an extended panel of clade B panel viruses
| HXB2 | SF162 | 6535.03 | SC422.8 | QH0692.42 | WITO.33 | MuLV | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Immunogen | Animals | wk 22 | wk 34 | wk 22 | wk 34 | wk 22 | wk 34 | wk 22 | wk 34 | wk 22 | wk 34 | wk 22 | wk 34 | wk 22 | wk 34 |
| DNA + Protein (MF59) | 41 | - | 587 | 12 | 5626 | - | - | - | 61 | - | - | - | - | - | - |
| 42 | - | 33 | - | 469 | - | - | - | 20 | - | 13 | - | - | - | - | |
| 43 | - | - | 39 | 2096 | - | 82 | - | - | - | - | - | - | - | - | |
| 44 | - | 301 | 19 | 7253 | - | 140 | - | - | - | - | - | - | - | - | |
| DNA + Protein (MF59/ODN7909) | 45 | - | 48 | 510 | 1182 | - | 20 | - | 65 | - | - | - | - | - | - |
| 46 | - | - | 17 | 2231 | - | 105 | - | - | - | - | - | 18 | - | - | |
| 47 | - | - | - | 4189 | - | - | - | 44 | - | - | - | 19 | - | - | |
| 48 | - | 2272 | - | 2643 | - | 79 | - | 42 | - | - | - | - | - | - | |
| DNA + Protein (MF59/ODN2395) | 49 | - | nd | 365 | nd | - | nd | - | nd | - | nd | - | nd | - | nd |
| 50 | - | - | 48 | 3300 | - | 95 | - | 25 | - | - | - | - | - | - | |
| 51 | - | 155 | 50 | 3135 | - | - | - | - | - | - | - | - | - | - | |
| 52 | - | 45 | 22 | 661 | - | - | - | - | - | - | - | - | - | - | |
| rAd + Protein (MF59) | 53 | - | 120 | 164 | 1260 | - | - | - | - | - | - | - | - | - | - |
| 54 | - | 19 | 41 | 151 | - | - | - | - | - | - | - | - | - | - | |
| 55 | - | - | 129 | 249 | - | - | - | - | - | - | - | - | - | - | |
| 56 | - | - | 592 | 1009 | - | - | - | - | - | - | - | - | - | - | |
| rAd + Protein (MF59/ODN7909) | 57 | - | 323 | 86 | 1065 | - | 85 | - | - | - | - | - | - | - | - |
| 58 | 18 | 59 | 179 | 750 | - | 24 | - | - | - | - | - | - | - | - | |
| 59 | - | 22 | 37 | 260 | - | - | - | - | - | - | - | - | - | - | |
| 60 | - | 164 | 5593 | 3892 | 570 | 387 | - | - | - | - | - | - | - | - | |
| rAd + Protein (MF59/ODN2395) | 61 | - | 170 | 144 | 1098 | - | - | - | - | - | - | - | - | - | - |
| 62 | 33 | 62 | 400 | 2145 | - | 198 | - | - | - | - | - | - | - | - | |
| 63 | - | 33 | 26 | 321 | - | 18 | - | - | - | - | - | - | - | - | |
| 64 | - | 39 | - | 218 | - | - | - | - | - | - | - | - | - | - | |
| Protein only (MF59) | 69 | 274 | 610 | 7181 | 9344 | - | 29 | - | - | - | - | - | - | - | - |
| 70 | 20 | 29 | 1176 | 1675 | - | - | - | - | - | - | - | - | - | - | |
| 71 | 392 | 450 | 9473 | 9855 | 76 | 58 | - | - | - | - | - | - | - | - | |
| 72 | 1689 | 2598 | 5856 | 8018 | 122 | 267 | - | - | - | - | - | - | - | - | |
| rAd empty vector | 65 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 66 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| 67 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| 68 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
The vaccine modalities are shown in the left column. The adjuvant, shown in parenthesis, was used with protein immunizations only. Value indicate the reciprocal serum dilution that resulted in 50% neutralization of each virus. Time points shown are week 22 and week 34. A dash (-) indicates that 50% neutralization was not resorded at the lowest serum dilution tested (1:10). nd indicates not determined.