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Cornified cell envelope–protein expression (original magnification ×400). Skin-biopsy sections obtained from a control individual (A, C, E, and G) and a patient (B, D, F, and H) were stained with antibodies directed against filaggrin (A and B), loricrin (C and D), involucrin (E and F), and keratin 1 (G and H) and were examined by light microscopy. Note the marked acanthosis (H) and thickened stratum corneum (indicated by an asterisk [*] in panel D) in affected skin.
