Table 1. .

Penetrance of the Craniofacial Phenotype in Different SMS Mouse Models at the N2 Generation (25% 129SvEvBrd and 75% C57BL/6)

		No. of Mice
Straina	Deletion Size	Examined	With Phenotype	Penetrance (%)
Df(11)17/+b	∼2 Mb	>50	…	70–80
Df(11)17-4/+c	∼1 Mb	49	29	59
Df(11)17-1/+	∼590 kb	54	26	48
Rai1−/+d	NAe	56	10	18

^aAll strains were maintained by backcrossing to C57BL/6 Tyr^c-Brd (B6) wild-type mice. Animals were treated in compliance with relevant animal welfare policies under a protocol approved by the Baylor Institutional Animal Care and Use Committee. For the penetrance comparison, Fisher's exact test was performed. P values <.05 were considered statistically significant.

^bData from Yan et al.¹⁷

^cGenotyping was performed with two pairs of primers: 5′ HPRT 2Ty (tyrosinase end) forward 5′-CTGGGAGAAAACATATTTTGAGAGA-3′ and reverse 5′-TTCCTGTTTGGGGTAGAATGTACT-3′ and 3033-2 5′-TCCCGATCAAGGTCAGGAACA-3′ and B1IN-R 5′-AAAAAGAAGTCAGGGGTTGG-3′.

^dData from Bi et al.¹⁸

^eNA = not applicable.