Fig. 5.
Regulating adaptive immunity. This figure exemplifies the proliferation curves that result from varying parameters known to be affected by signal strength and by external signal regulation such as cytokines. (A–C) Parameters altered are the means of times to division and death (A and B) and the average number of divisions undergone (C). Parameter values varied at equally spaced intervals from: (A) φ0 med = 30 h (darkest) to 60 h (lightest), s constant at 0.3 h and ψi>0 from 100 h to 50 h, s constant at 0.5 h; (B) φi>0 from 10 h to 20 h, s constant at 0.2 h and ψi>0 from 35 h to 16 h, s constant at 0.75. pF0 was set to 1.0 in all cases. Average division number (C) was defined by varying the mean of the division destiny distribution from Dμ = 12 (darkest) to Dμ = 5 (lightest), while keeping Dσ constant at 2. Possible outcomes are shown in D.