Figure 6.

Suppression of the ARO-induced tumor growth by Ad-Yas infection. (A) ARO cells were infected with either Ad-Yas (10 pfu per cell), Ad-Ys (10 pfu per cell), or Ad-lacZ (10 pfu per cell) and inoculated into eight athymic mice. (B) ARO cells (2 × 10⁶) were inoculated s.c. in 24 athymic mice, and, 3 days later, eight mice were treated in the area of the lesion with 5 × 10⁷ pfu of either Ad-Yas or Ad-lacZ. (C) ARO cells (2 × 10⁶) were inoculated s.c. in 24 athymic mice. Twenty days later, when the tumors were detectable, eight mice were treated once a week with 5 × 10⁷ pfu of either Ad-Yas or Ad-lacZ in the area of the lesion. (D) ARO cells (2 × 10⁶) were inoculated s.c. in 90 athymic mice, and, 3 days later, 30 mice of these were treated i.p. with 5 × 10⁸ pfu of either Ad-Yas or Ad-lacZ once a week. (E) ARO cells (2 × 10⁶) were inoculated s.c. in 90 athymic mice, and, 20 days later, when the tumors became visible, 30 mice were treated i.p. with 5 × 10⁸ pfu of either Ad-Yas or Ad-lacZ once a week.