Table 1.
Cytotoxic effect of Ad-Yas on neoplastic cells
| Tissue origin | Cell line | HMGI(Y) expression* | IC50 Ad-Yas, pfu/cell† |
|---|---|---|---|
| Rat thyroid normal cells | PC Cl 3 | ND | >1,000 |
| Rat thyroid transformed cells | PC MPSV | High | 10 |
| Human thyroid normal cells | HTC-2 | ND | >1,000 |
| Human thyroid cancer cells | ARO | High | 2.6 |
| FB-1 | High | 3 | |
| Human colon cancer cells | LoVo | High | 1 |
| GEO | High | 12.5 | |
| SW620 | High | 5 | |
| Human lung cancer cells | A549 | High | 9 |
| H1355 | High | 4.5 | |
| Human breast cancer cells | MCF-7 | High | 25 |
| MDA468 | High | 13 |
*
The level of endogenous HMGI(Y) in each cell line was determined by immunoblotting analysis. ND, not detectable.
† Values are estimated from the cell-killing experiment described in the text.