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. 2003 Sep 1;112(5):670–682. doi: 10.1172/JCI17991

Figure 3.

Figure 3

Histopathological analysis of LT-treated BALB/cJ mouse spleen. (a) Red pulp from PA-injected (48 hours) control. 40× objective. (b) Individual cell death in red pulp with relative sparing of white pulp at 6 hours after LT treatment. 40× objective. (c) Advanced necrosis in red pulp at 12 hours. 40× objective. (d) Hemorrhage in red and white pulp at 18 hours. 20× objective. (e) Hemorrhage in red and white pulp at 18 hours. 2× objective. (f) Resolution of cell death with restoration of extramedullary hematopoiesis (EMH) at 48 hours. 40× objective. Dosage was 100 μg PA (control) or 100 μg LT.

HHS Vulnerability Disclosure