Figure 3.

Histopathological analysis of LT-treated BALB/cJ mouse spleen. (a) Red pulp from PA-injected (48 hours) control. 40× objective. (b) Individual cell death in red pulp with relative sparing of white pulp at 6 hours after LT treatment. 40× objective. (c) Advanced necrosis in red pulp at 12 hours. 40× objective. (d) Hemorrhage in red and white pulp at 18 hours. 20× objective. (e) Hemorrhage in red and white pulp at 18 hours. 2× objective. (f) Resolution of cell death with restoration of extramedullary hematopoiesis (EMH) at 48 hours. 40× objective. Dosage was 100 μg PA (control) or 100 μg LT.