Figure 8.

LTβR-Ig treatment does not prevent EAE in a PTx-dependent model. (a) C57BL/6 mice were treated with control huIgG (diamonds) or LTβR-Ig (circles) 1 day prior to immunization with MOG_35–55 in CFA followed by injection of PTx on days 0 and 2. Limb paralysis was scored in all phases of the disease, and if animals were euthanized, they were given a score of 6 on that day of the study. Otherwise, scores reflect only viable animals. (b) Accompanying weight measurements for the experiment in a. The experiment was performed on 30 animals per group and repeated with similar results using less CFA and PTx.