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Schematic representation of different SDF configurations possible in SFHR-mediated modification of a target sequence. The SDF can interact with the target sequence as (a) sense and/or (b) antisense ssDNA, or as (c) dsDNA. The ssDNA can be introduced either as individual strands (sense and antisense) or as denatured cDNA strands. The enzymatic mechanisms involved require further elucidation.
