Table 1.
Group | n | DHEAS, μmol/liter
|
Testo, nmol/liter
|
ADG, nmol/liter
|
E2, pmol/liter
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
M0 | M6 | M12 | M0 | M6 | M12 | M0 | M6 | M12 | M0 | M6 | M12 | ||
Men <70 | |||||||||||||
DHEA | 36 | 2.90 ± 0.19 | 10.4 ± 0.92**†† | 7.22 ± 0.65**†† | 18.4 ± 1.1 | 20.9 ± 1.11 | 18.1 ± 0.91 | 14.3 ± 1.03 | 29.0 ± 2.42**† | 23.4 ± 2.98**† | 71 ± 2.7 | 78 ± 3.2 | 81 ± 2.4* |
Placebo | 31 | 2.65 ± 0.16 | 1.81 ± 0.19 | 2.66 ± 0.19 | 20.0 ± 1.15 | 18.7 ± 1.09 | 8.2 ± 0.96 | 15.2 ± 1.50 | 15.6 ± 1.67 | 16.2 ± 1.76 | 73 ± 3.8 | 73 ± 4.0 | 76 ± 3.7 |
Men >70 | |||||||||||||
DHEA | 30 | 2.44 ± 0.22 | 10.3 ± 1.06**†† | 8.98 ± 0.87**†† | 19.3 ± 1.12 | 20.6 ± 0.96 | 20.7 ± 1.17 | 13.7 ± 1.28 | 33.5 ± 3.06**† | 35.3 ± 3.61**† | 74 ± 3.4 | 76 ± 3.4 | 81 ± 4.4* |
Placebo | 36 | 2.14 ± 0.13 | 1.44 ± 0.16 | 2.00 ± 0.19 | 19.3 ± 1.48 | 20.1 ± 1.76 | 18.6 ± 1.81 | 14.0 ± 1.29 | 15.9 ± 1.88 | 15.1 ± 1.48 | 74 ± 3.0 | 79 ± 3.3 | 80 ± 3.4 |
Women <70 | |||||||||||||
DHEA | 35 | 2.01 ± 0.16 | 8.03 ± 0.71**†† | 5.24 ± 0.43**† | 1.30 ± 0.1 | 2.3 ± 0.1*† | 1.60 ± 0.1 | 4.5 ± 0.5 | 29.5 ± 3.6**†† | 20.5 ± 2.5**†† | 28 ± 1.8 | 39 ± 1.6**† | 37 ± 1.6**† |
Placebo | 35 | 2.19 ± 0.19 | 1.54 ± 0.16 | 2.11 ± 0.24 | 1.16 ± 0.08 | 1.3 ± 0.09 | 1.23 ± 0.08 | 3.9 ± 0.43 | 3.90 ± 0.36 | 4.2 ± 0.42 | 27 ± 1.3 | 29 ± 1.6 | 27 ± 1.9 |
Women >70 | |||||||||||||
DHEA | 31 | 1.66 ± 0.11 | 9.77 ± 1.09**†† | 7.19 ± 0.57**†† | 1.09 ± 0.09 | 2.35 ± 0.15*† | 1.92 ± 0.13*† | 3.3 ± 0.3 | 27.8 ± 2.0**†† | 26.4 ± 2.5**†† | 25 ± 1.2 | 37 ± 1.8**† | 35 ± 2.0**† |
Placebo | 34 | 1.81 ± 0.19 | 1.19 ± 0.13 | 1.57 ± 0.19 | 1.17 ± 0.11 | 1.31 ± 0.14 | 1.25 ± 0.12 | 3.8 ± 0.42 | 3.90 ± 0.47 | 3.90 ± 0.39 | 26 ± 1.4 | 26 ± 1.04 | 27 ± 1.7 |
*, P < 0.05; **, P < 0.01 vs. M0 of the same group. †, P < 0.05; ††, P < 0.01 vs. placebo group of same age and gender.