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RAD-mediated inhibition of in vivo growth of PTLD-like B cells; treatment of established tumors. Fragments of tumors derived from EBV+ B cell lines 15A, 20A, and A2D6 were implanted into recipient SCID mice. Treatment with 5 mg/kg/day of the drug was started when the tumors reached 5 mm in diameter (50 mm3 in volume). The numbers of mice per group are shown in parentheses; lines depicting results from some of the mice are superimposed, particularly in the RAD-treated mice.
